Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

In 94% of cases, ALGS is caused by mutations in JAG1, which encodes one of the ligands for the Notch pathway. Patients with mutations in N-glycanase 1 (NGLY1) exhibit a host of developmental ...

Jagged1 是乳腺中表达最丰富的 Notch 配体，然而其在乳腺中的功能尚不清楚。已有研究表明，Jagged1 在乳腺癌中的作用复杂，在不同细胞系中的表现各异，如在管腔型乳腺癌 MCF-7 细胞中敲低 JAG1 会增加肿瘤球生长和癌症干细胞活性，而在三阴性乳腺癌 SUM149 细胞中 ...

Notch1 is expressed uniformly throughout the mouse endocardium during the initial stages of heart valve formation, yet it remains unclear how Notch signaling is activated specifically in the AVC ...

Minecraft's original and hugely controversial creator Markus "Notch" Persson has cancelled plans for a spiritual successor to the mammoth block-building phenomenon, six whole days after he ...

Authorities say deputies responded to Room Service on Two Notch Road about shots being fired and a fight in progress. Upon arrival, deputies started to search for a vehicle that was reported to ...