p53 is a transcription factor that regulates the expression of genes involved in tumor suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of human cancers. p53 regulates ...

Notch 对维持 Ras 转化的人类细胞的肿瘤表型至关重要。 实验使用的小鼠品系包括由 Dr. Freddy Radtke 和 Dr. Nicholas Gaiano 分别提供的 Jag1 和 TNR 小鼠，以及从 Jackson Laboratory 和 NCI Mouse Repository 获得的 ...

Activation of the NOTCH1 receptor occurs when NOTCH ligands of the Jagged and Delta-like family bind to the extracellular subunit of NOTCH1. Ligand binding induces dissociation of the two subunits ...

在生命科学领域，信号通路的研究正日益成为推动重大科研突破的重要力量。最近，中山大学附属第二医院及其他科研机构联合发表的高影响力文章《Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer》，便充分展示了这一趋势。这项研究在《Cancer ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...