Genetics researchers studied eFAD families to discover the three known genes that cause familial AD: amyloid precursor protein (APP), presenilin-1 (PS1), and presenilin-2 (PS2). Of these, PS1 ...
Disruption of calcium homeostasis, inhibition of protein glycosylation, and various cellular stresses provoke the accumulation of unfolded protein in the endoplasmic reticulum (ER); this ...
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