Interactions at a ligand binding level had been proposed and were strengthened by mounting pharmacological evidence. Binding assays were critical in assessing the hypothesis that opioid receptors ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

We provide comprehensive molecular modeling solutions tailored specifically for ligand design with cutting-edge tools at our disposal. With specialized expertise in GPCRs (G protein-coupled receptors) ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...