The strength of theoretical approaches is in the simplification of complex biological systems. We here consider the general problem of receptor–ligand binding in the context of antibody–antigen ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

Figure 1 PD-1/PD-L1 signaling in T cells. When the receptor PD-1 binds to its ligand PD-L1, the PD-1 ITSM is phosphorylated at tyrosine residues, leading to the recruitment of protein tyrosine ...

After hours: February 6 at 4:20:00 PM EST Loading Chart for LGND ...

Ligand Pharmaceuticals is headquartered less than an hour north of me as the crow flies in Jupiter, FL. Ligand Pharmaceuticals has several products on the market as well as candidates in its ...

Investors took in Amazon earnings, with the all-important jobs report on deck. There are a number of stocks moving in after-hours trading.  E.l.f. Beauty (ELF) shares fell sharply after ...

Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1 ... protein 3 or the adenosine receptor A2aR. Recent data suggest that ...

ligand APRIL (A Proliferation Inducing Ligand) were found in synovial fluid and serum of patients with inflammatory arthritis pointing to a pro-inflammatory role of APRIL. APRIL can bind to BCMA and ...

Fintel reports that on February 7, 2025, Citigroup initiated coverage of Viking Therapeutics (NasdaqCM:VKTX) with a Neutral ...

Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...