The phase 1 trial enrolled 115 people to test single and multiple ascending doses of the oral, once-daily TREM2 agonist VG-3927. Vigil included an elderly cohort and a single dose arm of 11 ...

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Ligand Pharmaceuticals Incorporated, a biopharmaceutical company, engages in the development and licensing of biopharmaceutical assets worldwide. Its commercial programs include Kyprolis and ...

Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have divulged triggering receptor expressed on myeloid cells 2 (TREM2) agonists reported to be useful for the treatment of amyotrophic lateral ...

【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议 ...

【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议。 1月21日，新疆石河子大学研究团队在期刊《Journal of Experimental & Clinical Cancer Research》上发表了研究 ...

Increasing evidence supports the notion that neuroinflammation plays a critical role in the etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their capacity ...

For instance, chemokines such as CC-chemokine ligand 2 (CCL2) and chemokines including chemokine ligand 10 are produced ... For example, recent discoveries have identified a novel subpopulation of ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...