Although the roles of the newly recognized polymerases are still being defined, one of their crucial functions is to allow synthesis past DNA damage that blocks replication-fork progression.

University of Science and Technology of China, Hefei 230026, China ...

DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the ...

[Editors' note: this paper was reviewed by Review Commons.] Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature ...

By computationally targeting DDR replication and repair ... to regulate protein function. For proteins in macromolecular complexes, the best results aim to define the interaction of the ligand binding ...

Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin–angiotensin system (RAS) is involved in the regulation of ...

Fanconi anemia (FA) is a rare genetic disorder characterized by defective DNA repair, leading to hematopoietic stem cell (HSC) dysfunction and bone marrow failure. Replication stress, which ...

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

Learning about your genetics and ancestry is easier than ever. All you need to do is choose from the many DNA ancestry tests available online, receive your kit and send back the required DNA samples.