The inhaled monoclonal antibody IN-006 shows promise in COVID-19 treatment, with high airway antibody levels and a favorable safety profile in healthy adults.
University of Udine, Via Palladio 8, Udine 33100, Italy hDepartment of Medical Oncology, CRO Aviano, National Cancer Institute, IRCCS, Via Franco Gallini 2, Aviano, Pordenone 33081, Italy iDepartment ...
The theory behind antibody drug conjugates (ADCs) is simple yet elegant: by combining the specificity of a monoclonal antibody with the cytotoxicity of a potent small molecule drug, ADCs can ...
In cancer, antibodies can target tumour cells directly for destruction (e.g., antibody-drug conjugates) or amplify the immune response (e.g., ADCC, CDC, bispecifics). In autoimmune diseases ...
These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss of response. Fully human biological agents, such as the anti-tumour necrosis factor α ...