Further experiments revealed that lubricin suppresses the production of urate and an enzyme called xanthine oxidase (which creates urate), while also preventing urate from crystallizing in the joint.

Objective: To clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout. Methods: We retrospectively analyzed 237 male gout patients who ...

1 Department of Orthopaedics, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China 2 College of Nursing, Hangzhou Normal University, Hangzhou, China Objective: Gout is a common ...

Urate-lowering therapies are the preferred medication for most individuals with gout. Options include: Benemid (probenecid): This is a uricosuric medication. This drug increases excretion of uric acid ...

Objective To test the hypothesis that gouty arthritis (gout) is a risk factor for incidence of heart failure and for echocardiographic measures signifying subclinical heart failure. Design Post-hoc, ...

Urate-lowering therapies are the preferred medication ... Zyloprin (allopurinol), Uloric (febuxostat): These drugs are called xanthine oxidase inhibitors (XOIs). They reduce the body’s ...

OBJECTIVES To study the efficacy of allopurinol and benzbromarone to reduce serum urate concentrations in patients with primary chronic gout. METHODS Prospective, parallel, open study of 86 ...

Objectives To evaluate the sensitivity to change of ultrasound structural gout lesions, as defined by the Outcome Measures in Rheumatology (OMERACT) ultrasound group, in patients with gout during ...

2 Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands Objectives Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) ...