A 41-year-old man was evaluated for swelling in the ankles and syncope. CT of the chest showed bilateral mediastinal and ...

For decades after the identification of mpox in humans in the Democratic Republic of Congo (DRC) in 1970, the disease was largely confined to the rural areas of Central and West Africa and thus ...

Two patients with congenital generalized lipodystrophy type 1 due to a variant in AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to tirzepatide and were ...

Rifampin-resistant tuberculosis has traditionally been treated with 18-to-24-month regimens, but shorter, all-oral regimens may offer efficacious alternatives. New research findings are summarized ...

For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now ...

Supported in part by grants (JP18K09018, to Dr. Ito, and 21H05046, to Dr. Takayanagi) from the Japan Society for the Promotion of Science KAKENHI program, by a grant (JPMJFR205Z, to Dr. Okamoto ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

To the Editor: The results of the SENIOR-RITA (Older Patients with Non–ST-Segment Elevation Myocardial Infarction Randomized Interventional Treatment) trial by Kunadian et al. (Nov. 7 issue) 1 ...

This feature about a child unvaccinated against measles, mumps, and rubella offers a case vignette accompanied by two essays, one supporting accepting the child as a patient without mandating the ...

A previously healthy 10-month-old girl presented with an intermittently itchy and swollen skin lesion on the neck. When rubbed, the lesion became edematous with a flare of surrounding erythema.

The best multimodal approach for resectable locally advanced esophageal adenocarcinoma is unclear. An important question is whether perioperative chemotherapy is preferable to preoperative ...