The phase 1 trial is testing the safety tolerability, pharmacokinetics, and pharmacodynamics of PVT201 in healthy volunteers and patients.

Associations between therapies and quality of life (QoL) in patients with generalized pustular psoriasis (GPP) can differ substantially.

The decision to terminate the HYPERION trial reflects a loss of clinical equipoise, making it unethical to continue the placebo-controlled study.

Patients with ATTR-PN have a high rate of comorbidities and substantial direct healthcare and economic burdens, a study found.

AGEP can closely mimic generalized pustular psoriasis (GPP), requiring histopathologic confirmation and assessment of peripheral eosinophilia.

Although a biopsy is essential to diagnose IgG4-RD and AAV, in those cases in which a biopsy cannot be performed, clinical features and supportive imaging or laboratory data may provide important ...

Patients with GPP who experienced flares had higher hospitalization rates (12.2% vs 6.9%) compared to those who did not flare. Patients with generalized pustular psoriasis (GPP) who experience flares ...

Iptacopan shows promise in reducing fatigue and improving function in patients with PNH. Iptacopan resulted in meaningful improvements across a number of key clinical parameters in patients with ...

A little more than a third (36.1%) of patients with Huntington disease (HD) and chorea are taking an anti-chorea medication, a study found.

Daily supplementation of beta-hydroxy-beta-methylbutyrate (HMB) could improve overall daily activity in Duchenne muscular dystrophy (DMD), a study found.

Surgical resection significantly improved overall survival and cancer-specific survival in primary central nervous system lymphoma (PCNSL).

TDP43 seems to worsen the inflammatory activation of astrocytes in neuromyelitis optica spectrum disorder (NMOSD), a study found.