Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the emergent ...

Here, we perform a systematic review of the species-specific features of the segmentation clock with a keen focus on mouse embryos. We perform this review using three different perspectives: ...

Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

The Notch signaling pathway plays important roles in animal embryonic development and adult maintenance. We and others have shown that addition of O-linked glycans (carbohydrates) to Notch EGF repeats ...

Activation of the NOTCH1 receptor occurs when NOTCH ligands of the Jagged and Delta-like family bind to the extracellular subunit of NOTCH1. Ligand binding induces dissociation of the two subunits ...

A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Authorities say deputies responded to Room Service on Two Notch Road about shots being fired and a fight in progress. Upon arrival, deputies started to search for a vehicle that was reported to ...