Anti-CD20 mAbs were originally created to treat B cell proliferative diseases such as non-Hodgkin's lymphoma and chronic ...

This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor ...

In addition, CD32B is expressed by human and mouse B cells and functions as an inhibitory receptor that blocks antibody production (10). We did not observe 4A5 staining of canine B cells. Dogs also ...

IgM is the first antibody to be produced in a humoral immune response and plays an important role in the primary stages of immunity. Here we describe a mouse Fc receptor, designated Fcα/μR ...

The Vivacity-MG3 study is currently in its open-label extension phase, which is investigating the longer-term safety and ...

HOUSE, Pa. - Johnson & Johnson (NYSE: NYSE:JNJ) has released new data on nipocalimab, an investigational drug with potential to treat diseases driven by immunoglobulin G (IgG) antibodies. Published in ...

Johnson & Johnson has unveiled groundbreaking findings on nipocalimab, an investigational FcRn blocker, in a recent ...

Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain ...

lumc.nl Objective To determine whether anticitrullinated protein antibodies (ACPA) exhibit specific changes in Fc glycosylation prior to the onset of arthritis. Methods Serum samples of patients with ...

1 Pathogenic antibodies directed against antigens such as the postsynaptic acetylcholine receptor (AChR), muscle-specific tyrosine kinase (MuSK), and LDL receptor-related protein type 4 (LRP4) have ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...