These ligands in turn bind to Notch receptors (Notch1 and 4) in the adjacent cells, which results in sequential proteolytic cleavages by ADAM and γ-secretase, which release the NICD into the nucleus.

Notch signaling has been identified as a key regulatory pathway in patterning the ... For detection of low-abundance targets such as NICD and phospho-PKC Ser660, tyramide signal amplification (TSA) ...

Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

米托蒽醌作为 Usp11 的抑制剂，给予野生型小鼠米托蒽醌处理后进行 TBI，结果显示米托蒽醌干预使 Usp11+/+ 小鼠脾脏边缘区变窄，减轻了电离辐射后 MZ B 细胞数量的减少。流式细胞术分析表明，米托蒽醌处理后，Usp11+/+ 小鼠受 TBI 后 MZ B 细胞的总百分比显著高于 PBS 处理组，且血清 IgM 水平变化表明米托蒽醌干预减少了抗体类型的转变。这说明靶向 Usp11 ...

It is part of the Notch signaling pathway ... releasing the Notch1 intracellular domain (NICD). NICD travels to the nucleus, where it switches on genes that drive cell growth, division, and ...

Such non-canonical regulation of YAP/TAZ includes well-known growth factor signaling pathways such as the epidermal growth factor receptor (EGFR)/ErbB family, Notch, and Wnt signaling as well as ...

Saving money can be a challenge in an economy with persistent inflation. After all, if your money doesn't earn a return that's at least equal to inflation, it will lose buying power. But, a ...