The finance minister has called for clarity around funding to cover the increase in employers' National Insurance contributions from April. Since the Budget last October, Caoimhe Archibald has ...

Authorities say deputies responded to Room Service on Two Notch Road about shots being fired and a fight in progress. Upon arrival, deputies started to search for a vehicle that was reported to ...

These ligands in turn bind to Notch receptors (Notch1 and 4) in the adjacent cells, which results in sequential proteolytic cleavages by ADAM and γ-secretase, which release the NICD into the nucleus.

Plus, news about Neur­i­zon: WuXi AppTec di­vests again: The com­pa­ny is sell­ing its US med­ical de­vice test­ing op­er­a­tions, in­clud­ing fa­cil­i­ties in Min­neso­ta and ...

Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

Notch signaling has been identified as a key regulatory pathway in patterning the ... For detection of low-abundance targets such as NICD and phospho-PKC Ser660, tyramide signal amplification (TSA) ...

Also, this observation does not explain the link between PKC activity and Notch activation. As PMA is a well-characterized specific activator of PKC, we believe the rescue of NICD by PMA could explain ...

1The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York. 2Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

It is part of the Notch signaling pathway ... releasing the Notch1 intracellular domain (NICD). NICD travels to the nucleus, where it switches on genes that drive cell growth, division, and ...

The health minister has warned that his budget allocation means that the health and social care system is facing "more of the same" this year. The Northern Ireland Executive agreed a draft budget ...