Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the emergent ...

Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

In 94% of cases, ALGS is caused by mutations in JAG1, which encodes one of the ligands for the Notch pathway. Patients with mutations in N-glycanase 1 (NGLY1) exhibit a host of developmental ...

Here, we perform a systematic review of the species-specific features of the segmentation clock with a keen focus on mouse embryos. We perform this review using three different perspectives: ...

Jagged1 是乳腺中表达最丰富的 Notch 配体，然而其在乳腺中的功能尚不清楚。已有研究表明，Jagged1 在乳腺癌中的作用复杂，在不同细胞系中的表现各异，如在管腔型乳腺癌 MCF-7 细胞中敲低 JAG1 会增加肿瘤球生长和癌症干细胞活性，而在三阴性乳腺癌 SUM149 细胞中 ...

Republicans in Minnesota's progressive-dominated government have notched a temporary majority in the House through a power-sharing agreement reached Thursday after Democrats refused to show up to ...

Notch1 is expressed uniformly throughout the mouse endocardium during the initial stages of heart valve formation, yet it remains unclear how Notch signaling is activated specifically in the AVC ...

此后，Notch 配体 JAG1 等风险基因相继被发现。 然而，近20年，Notch 信号通路基因异常导致胸主动脉瘤的具体机制仍不明确，存在机械力假说与基因调控假说的争议。机械力假说认为瓣膜发育畸形造成的长期血流动力改变是主要致病因素；而基因调控假说则强调 ...

Authorities say deputies responded to Room Service on Two Notch Road about shots being fired and a fight in progress. Upon arrival, deputies started to search for a vehicle that was reported to ...