These ligands in turn bind to Notch receptors (Notch1 and 4) in the adjacent cells, which results in sequential proteolytic cleavages by ADAM and γ-secretase, which release the NICD into the nucleus.

Notch signaling has been identified as a key regulatory pathway in patterning the ... For detection of low-abundance targets such as NICD and phospho-PKC Ser660, tyramide signal amplification (TSA) ...

Minecraft creator Markus ‘Notch’ Persson has seemingly announced that he intends to start working on Minecraft 2 in a post on social media. In typical Notch style, he has been very active and ...

For a short while, this seemed like a genuine possibility, as Markus ‘Notch’ Persson pitched the idea of making his own ‘Minecraft 2’ sandbox game. However, it now seems like that dream is ...

S3 cleavage is the modification of the residual part by γ-secretase to form the soluble Notch intracellular domain (NICD). Itchy E3 ubiquitin-protein ligase (ITCH), an E3 ubiquitin ligase, mitigates ...

Markus "Notch" Persson has "basically announced" Minecraft 2. In an X exchange over the New Year, Persson invited his millions of followers to indicate which project they'd like him to focus on in ...

The original creator of Minecraft Notch started a poll on X after expressing interest in making a spiritual successor to Minecraft. Over 75% of the community voted yes to a Minecraft 2, making the ...

The National Institute for Communicable Diseases (NICD) has issued a statement assuring the public that there is no need to panic about the reported cases of human metapneumovirus (HMPV). “This ...

Minecraft's original and hugely controversial creator Markus "Notch" Persson has cancelled plans for a spiritual successor to the mammoth block-building phenomenon, six whole days after he ...

Minecraft creator Markus ‘Notch’ Persson has announced that he wants to make another game, and it looks like it’ll be a spiritual sequel to the biggest sandbox game in the world. Persson ...

Notch has announced he’s “basically” working on a Minecraft 2 project, yet the series creator assures it won’t infringe on the copyright owned by Microsoft. Minecraft creator Markus ...