Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen ...

【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议。 1月21日，新疆石河子大学研究团队在期刊《Journal of Experimental & Clinical Cancer Research》上发表了研究 ...

VigilNeuroscience今日宣布，其用以治疗阿尔茨海默病（AD）的在研TREM2小分子疗法VG-3927在1期临床试验中获得积极数据。分析显示，该疗法具有高度脑 ...

【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议 ...

The phase 1 trial enrolled 115 people to test single and multiple ascending doses of the oral, once-daily TREM2 agonist VG-3927. Vigil included an elderly cohort and a single dose arm of 11 ...

Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have divulged triggering receptor expressed on myeloid cells 2 (TREM2) agonists reported to be useful for the treatment of amyotrophic lateral ...

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Trem2 knockout mice showed remarkable reductions in prelimbic synaptic pruning and ... Twenty-one days after microinjection, hM4D(Gi)/hM3D(Gq) was activated by the selective ligand clozapine N-oxide ...

TREM2 ligand Amyloid, which is well-studied, is a crucial pathogenic protein in Alzheimer’s disease. B7-H3, a well-studied TLT-2 ligand, is essential for adaptive immune responses. The ...