此外，近年来可变多聚腺苷酸化（Alternative polyadenylation，APA）作为基因表达调控的关键机制受到关注。APA 可以影响 RNA 3’端的形成，进而影响 RNA 的稳定性、核糖体加载和翻译效率，这些过程都与疾病的发展密切相关。例如，甲型流感病毒（IAV）菌株能诱导宿主细胞发生 APA，参与抗病毒反应，而 APA 的缺失会导致小鼠炎症反应增加和毒力降低，表明 APA ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Although inflammation has been widely ...

Given that the role of PRMT1 in metabolic regulation has been well-documented, we then investigated whether PRMT1 is involved in transforming 6133 cells through metabolic reprogramming. To assess this ...

This valuable study presents data suggesting the critical roles of two ancient proteins, XAP5 and XAP5L, in regulating the transcriptional program of ciliogenesis during mouse spermatogenesis. The ...

Feb. 10, 2025 — Evolution is traditionally associated with a process of increasing complexity and gaining new genes. However, the explosion of the genomic era shows that gene loss and ...

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What’s your purpose in life? It’s a daunting question. But your answer may say a lot about your well-being. Studies link a sense of purpose to better physical and mental health. But your purpose isn’t ...

Feb. 12, 2025 — A collaboration of researchers surveyed zoo employees and volunteers across the US about their experiences of burnout and grief related to zoo animal ...