2021年4月20日 · People with red hair have a variant of the melanocortin-1 receptor (MC1R) gene. This gene controls the production of melanin, the pigment that gives skin, hair, and eyes their color. The cells that make melanin produce two forms—eumelanin and pheomelanin.

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms o...

The MC1R gene provides instructions for making a protein called the melanocortin 1 receptor. Learn about this gene and related health conditions.

The melanocortin 1 receptor (MC1R) is a melanocytic G s protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma-prone phenotype due to defective epidermal melanization and sub-optimal DNA repair.

2024年12月25日 · MC1R (Melanocortin 1 Receptor) is a Protein Coding gene. Diseases associated with MC1R include Skin/Hair/Eye Pigmentation, Variation In, 2 and Melanoma, Cutaneous Malignant 5. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

2023年12月20日 · The Mc1r gene, also known as the melanocortin 1 receptor gene, plays a significant role in determining the pigmentation of hair and skin. This gene is located on chromosome 16 and is responsible for producing a protein that helps control the production of the pigment melanin.

Melanocortin-1 receptor (MC1R) is a seven-transmembrane G protein–coupled receptor, encoded by the gene MC1R on 16q24.3 (1). Endogenously activated by the melanocyte-stimulating hormone and the adrenocorticotropic hormone, this receptor is a critical component of skin and hair pigment biosynthesis.

What is the melanocortin 1 receptor gene? The melanocortin 1 receptor (MC1R) gene encodes the receptor of melanocortin-stimulating hormone (also referred to as melanocyte-stimulating hormone or MSH), which is found on the surface of melanocytes.

The MC1R is, therefore, a major determinant of sun sensitivity and a genetic risk factor for melanoma and non-melanoma skin cancer. Recent work suggests that the MC1R also shows a clear heterozygote effect on skin type, with up to 30% of the population harbouring loss-of-function mutations.

2023年12月20日 · The MC1R gene, also known as the ginger gene, is responsible for producing a pigment called pheomelanin, which gives hair its red color. This gene mutation resulted in a higher concentration of pheomelanin in the hair follicles, leading to …