2023年8月13日 · 68Ga-FAPI 是一种有广阔临床应用前景的新型广谱肿瘤显像剂，在大部分肿瘤中表现出较之 18F-FDG 更高的肿瘤/本底比，图像对比度更好，甚至显示出更多病灶。 0168Ga-FAPI带来了什么？ 68Ga-FAPI 的发现，给患者打开了一扇新的大门，为癌症患者的诊断和治疗提供了极大的帮助。 在一些组织修复重塑的过程中，例如伤口愈合，纤维细胞会被几种因子激活，包括 TGFβ1，导致成纤维细胞活化蛋白的产生。 这种蛋白质在癌症的相关纤维细胞中会异常地 …

2023年1月3日 · Gallium 68 (68 Ga)–labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is based on the molecular targeting of the FAP, which is known to be highly expressed in the major cell population in tumor stroma, termed cancer-associated fibroblasts.

2019年6月1日 · FAP is overexpressed by cancer-associated fibroblasts of several tumor entities. Here, we quantify the tumor uptake on 68Ga-FAPI PET/CT of various primary and metastatic tumors to identify the most promising indications for future application.

2024年2月20日 · 该研究利用一种检测成纤维细胞活化蛋白的放射性分子探针68Ga-FAPI进行正电子发射断层扫描/计算机断层扫描 (PET/CT)成像，在临床试验中发现，腹膜或肝脏转移结直肠癌患者不仅肿瘤高摄取68Ga-FAPI，且68Ga-FAPI PET/CT强阳性的肿瘤浸润免疫细胞显著减少，并对PD-1免疫治疗药物响应不佳。 作者分析了131名进行68Ga-FAPI PET/CT和18F-FDG PET/CT扫描的转移性结直肠癌患者，发现无论是肝脏转移还是腹膜转移的结直肠癌患者68Ga-FAPI …

Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts of several tumor entities. The recent development of quinoline-based PET tracers that act as FAP inhibitors (FAPIs) demonstrated promising results preclinically and already in a few clinical cases. Consequently, th …

2023年5月12日 · In contrast to tumor entity-specific imaging strategies such as prostate-specific membrane antigen (PSMA) ligand–based PET, FAPI-PET is based on the universal approach of targeting the activated fibroblasts (cancer-associated fibroblasts: CAFs) which primarily addresses the cancer stroma (tumor microenvironment).

2024年1月4日 · 68 Ga-FAPI PET/CT accurately monitors the dynamic changes of CAFs by TGF-β inhibition to assess tumor immunity and predict tumor response to ICBs in peritoneal metastatic CRC. Peritoneal metastasis is common in CRC patients, with poor prognosis and limited treatment options .

The recent development of quinoline-based PET tracers that act as fibroblast-activation-protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is overexpressed by cancer-associated fibroblasts of several tumor entities. Here, we quantify the tumor uptake on …

本文主要从以下几方面进行论述： 第一部分:肿瘤相关成纤维细胞对非小细胞肺癌顺铂化疗疗效的影响及68Ga-FAPI PET/CT分子影像学研究 目的:肺癌是癌症相关死亡的主要原因，新型放射性示踪剂正电子核素镓-68(Gallium-68，68Ga)标记的成纤维细胞激活蛋白抑制剂(Fibrillation activation protein inhibitors，FAPI)近年来 ...

2022年5月16日 · 近日，厦门大学附属第一医院核医学科及闽南PET中心团队在医学影像领域顶级期刊《Radiology》（JCR Q1区，IF=11.105）正式发表了题为“68Ga Fibroblast Activation Protein Inhibitor PET/CT in the Detection of Metastatic Thyroid Cancer: Comparison with 18F-FDG PET/CT”的研究论著，并获Radiology官网首页推荐论文。 该研究首次将68Ga-FAPI PET/CT与常规18F-FDG PET/CT在转移性甲状腺癌患者中进行了前瞻性的头对头比较。 厦门大学附属第一医 …