Ysabel Jurado is the Newly Elected Councilmember for Los Angeles City Council District 14. Council District 14 in Los Angeles covers diverse neighborhoods like Boyle Heights, Downtown Los Angeles and parts of Northeast Los Angeles. A new website will be launching soon.

CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. [5] [6] It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP).

The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages and monocytes. However, roles for CD14 are increasingly ...

cd14.lacity.gov Los Angeles's 14th City Council district is one of the fifteen districts in the Los Angeles City Council . The district, which has a large Latin American population, includes the neighborhoods of Boyle Heights , Downtown Los Angeles and parts of Northeast Los Angeles .

Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters.

2024年12月24日 · CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Alagille Syndrome 1 and Croup. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

2019年8月1日 · CD14 helps oxPAPC to be transported into cytoplasm to bind with caspase-11 and lead to NLRP3 inflammasome assembly and secretion of IL-1 and IL-18. This CD14-mediated oxPAPC endocytosis induces an inflammasome-dependent state of …

CD14 is a glycolipid-anchored membrane glycoprotein expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. CD14 is a key molecule in the activation of innate immune cells and exists as a membrane-anchored or soluble form.

2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses.

Here, CD14 function, its expression in different cell types and the regulation of expression, including the generation of soluble CD14, are described, and the diagnostic value of CD14 in various diseases is discussed.