Buy high-quality Z-IETD-FMK, a potent and selective inhibitor of Caspase-8. Functionally validated in TNF-α-induced necroptosis cellular assays. Each lot is highly pure (≥95%) and free of bacterial contaminations.

Many different viruses encode FLIP proteins, including several herpesviruses and the molluscum contagiosum virus (MCV) that encodes two distinct vFLIPs, MC159 and MC160. The HCMV gene product vICA (inhibitor of caspase activation) encodes an unrelated caspase-8 inhibitor (Table 1).

2021年10月15日 · The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia. Sci Transl Med. 2016;8:ra69.

Biochemically, caspase-8 was found to enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 (mucosa-associated lymphatic tissue) adapter complex which were crucial for the induction of nuclear translocation of NF-κB. Moreover, the biochemical form of caspase-8 differed in the two pathways.

In recent years, caspase-8 inhibitors have gained significant attention for their ability to control caspase-8 mediated cell death or other physiological functions. Caspase-8 inhibitors can be broadly categorized into broad-spectrum caspase inhibitors and caspase-8-specific inhibitors.

2023年7月18日 · Lentini et al. show that caspase-8 negatively regulates—in neutrophils—a spontaneous pro-inflammatory pathway driven by the RIPK3 kinase and sustained by interferon-β. By unleashing this pathway, pharmacological caspase-8 inhibition induces neutrophil mobilization and can effectively treat bacterial infections.

2006年9月8日 · These results suggest that irreversible inhibitors, and ones that tackle initiator caspases (e.g. caspase 8, caspase 9) or have broad-spectrum activity, would be more effective in vivo.

Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8. AP20187 (B/B Homodimerizer) is a chemical inducer of dimerization that activates FKBP-Casp8. Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE (OMe)TD (OMe)-FMK) is a specific Caspase-8 inhibitor. Z-IETD-FMK is also an inhibitor of granzyme B.

Caspase-8 inhibitor | C30H43FN4O11 | CID 44135212 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi.