Within the immune system, Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary …

Stronger BCR signals favour the development of follicular type I B cells, and weaker signals favour the development of marginal zone B cells. Tonic BCR signalling and B cell-activating...

2018年3月30日 · 因此，对于那些刚刚从骨髓中幸存并且游出来的B细胞，它们如果在周边系统中一上来就发生了很强的(cross-linking)反应，那么会被立即削减；如果和可溶的分子发生反应， …

Follicular B cells (B2 B cells) are the predominant type in the spleen and lymph nodes and a minor component of lymphocytes in the peritoneal cavity and bone marrow. B2 cells participate in the …

FOB可通过与辅助性T细胞 (Th)相互作用产生生发中心 (GC)，并历经类别转换重组 (CSR, class switch recombination)和体细胞超突变 (SHM, somatic hypermutation)，最终生成高亲和力抗体 …

2007年5月10日 · This review incorporates up-to-date information on peripheral B-cell differentiation into a challenging working model, thereby pointing to the structural and …

Follicular B cells are perhaps the most versatile B-cell subtype. These cells recirculate throughout the secondary lymphoid organs, and upon antigen encounter generate antibody secreting …

2024年11月23日 · Follicular B cells populate the B cell follicles of the spleen and lymph nodes, associating with follicular dendritic cells. They have a mature B cell phenotype that is distinct …

Mature follicular B cells, also referred to as B2 or “conventional” B cells, encompass the majority (>80%) of B lymphocytes in peripheral tissues, and are to be the progenitors of both primary …

2001年5月5日 · The enhanced maturation of follicular B cells is accompanied by the absence of MZ B lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which …