In mice the IgG class is divided into five sub-classes (IgG1, IgG2A, IgG2B, IgG2C and IgG3) and in rat there are four (IgG1, IgG2A, IgG2B, IgG2C). Sub-class nomenclature has arisen independently for each species and so there is no general relationship between the sub-classes from each species.

Immunoglobulin G (IgG) is one of the most abundant proteins in human serum, accounting for about 10–20% of plasma protein. It is the major class of the five classes of immunoglobulins in human beings, IgM, IgD, IgG, IgA, and IgE.

Human IgG2 antibody displays distinct therapeutically-useful properties compared with the IgG1, IgG3, and IgG4 antibody subclasses. IgG2 is the second most abundant IgG subclass, being able to bind human FcγRII/FcγRIII but not to FcγRI or complement C1q.

2012年6月14日 · It follows that all activating mouse FcγRs (FcγRI, FcγRIII, and FcγRIV) bind to IgG2a and IgG2b, whereas FcγRIII is the only activating FcγR binding IgG1 and FcγRI the only activating FcγR binding IgG3.

What is IgG2b? Immunoglobulin G (IgG) is the most abundant Ig isotype in serum, making up approximately 80% of all serum Immunoglobulins. In mice, the IgG subclasses are deas fined IgG1, IgG2a/c, IgG2b, and IgG3.

2020年7月15日 · The ability of some IgG subclasses (i.e., IgG2a, IgG2b, and IgG2c) to enhance alloimmunity to an RBC antigen contradicts the current “dual effect” model, in which IgG against soluble antigens enhances immunity whereas IgG against an RBC alloantigen suppresses .

'Immunoglobulin G2b' refers to a subtype of IgG antibodies characterized by specific heavy chain constant regions, which play a crucial role in defining its effector functions in the immune system. You might find these chapters and articles relevant to this topic. ROALD NEZLIN, in The Immunoglobulins, 1998.

The current studies were aimed at investigating why certain murine anti-CD3 isotypes (e.g. IgG2b) were poor activators of human T cells despite binding to the same epitope as the IgG2a anti-CD3. Most experiments were conducted with a human T cell line (HuT-78) and U937 a human histiocytic cell line …

Here we highlight the robust reliability of the simultaneous use of multiple mouse monoclonal antibodies (mAbs) of different immunoglobulin G (IgG) subclasses in a wide variety of multiplexing applications employing anti-mouse IgG subclass-specific secondary antibodies (2°Abs).

iGlycoMab is a purified murine IgG2b monoclonal antibody that has all glycan nitrogen atoms replaced by the stable-isotope 15N. You might find these chapters and articles relevant to this topic. Sidonia Mihai, Falk Nimmerjahn, in Autoimmunity Reviews, 2013.