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The melanocortin 1 receptor (MC1R) is a specialized G protein-coupled cell surface receptor ...

MC1R gene location on chromosome 16p24.3. Retrieved from... | Download Scientific Diagram

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IJMS | Free Full-Text | MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair

Simplified scheme of the intracellular signaling of the MC1R including... | Download Scientific ...

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The signaling pathways of MC1R and ENDBR modulate the DNA damage... | Download Scientific Diagram

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Gene Set Enrichment Analysis of MC1R in CRC. (A) Volcano plots were... | Download Scientific Diagram

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Structure of the MC1R receptor and the variant alleles that are... | Download Scientific Diagram

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IJMS | Free Full-Text | Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects

The role of MC1R signaling in anti-inflammatory effects. | Download Scientific Diagram

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Science Types: The genetic wonders of red hair

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Genes | Free Full-Text | Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention

The MC1R Gene and Youthful Looks: Current Biology

MC1R Polyclonal Antibody (PA5-75342)

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Modules of co-regulated genes in migrating HAoECs upon MC1R activation.... | Download High ...

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Secondary structure of MC1R and protein sequence alignment of MC1R... | Download Scientific Diagram

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MC1R gene location on chromosome 16p24.3. Retrieved from... | Download Scientific Diagram

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| Model of the MC1R secondary structure with 7 core domains and a rich... | Download Scientific ...

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Dienekes’ Anthropology Blog: Neandertal origin of MC1R haplotypes related to skin color

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Linkage map of ECA3 containing the MC1R gene. This linkage map is based... | Download Scientific ...

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Copilot 答案
Wikipedia
https://en.wikipedia.org/wiki/Melanocortin_1_receptor
Melanocortin 1 receptor - Wikipedia
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary pe…
Functions
The MC1R protein lies within the cell membrane, and is signalled by melanocyte-stimulating hormone (MSH) released by the pituitary gland. When activated by one of the variants of MSH, typically α-MSH, MC1R initiates … 展开
Melanocortin 1 receptor gene - DermNet
DermNet
Ligands
• α-MSH - nonselective peptide full agonist
• β-MSH - nonselective peptide full agonist
• γ-MSH - nonselective peptide full agonist
• ACTH - nonselective peptide full agonist… 展开
Pigmentation genetics
MC1R gene expression is regulated by the microphthalmia-associated transcription factor (MITF). Mutations of the MC1R gene either can create a receptor that constantly signals, even when not stimulated, or can lower the recept… 展开
Evolution
• MC4R
• MC3R
• MC5R
• MC2R
• GPR6
• GPR12… 展开
CC-BY-SA 许可证中的维基百科文本

维基百科
https://zh.wikipedia.org › wiki
黑素皮质素受体1 - 维基百科，自由的百科全书
黑素皮质素受体1 (mc1r)是一种g蛋白耦合受体，长度约为310个氨基酸左右，其基因序列只有一个外显子, 有7个跨膜结构域, 是最小的g蛋白耦合受体 [7] 。 MC1R是参与调节动物皮肤和毛发 …
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DermNet
https://dermnetnz.org › topics › melanocortin
Melanocortin 1 receptor gene - DermNet
2023年10月26日 · MC1R is maps to chromosome 16q24.3, meaning it is located on the long arm of chromosome 16, in position 24.3 near the telomere (the protective cap at the end of the chromosome that shortens with every …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Melanocortin 1 Receptor: Structure, Function, and Regulation
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and …
MedlinePlus
https://medlineplus.gov › genetics › gene
MC1R gene - MedlinePlus
Certain genetic changes in the MC1R gene modify the appearance of people with oculocutaneous albinism type 2. This form of albinism, which is caused by mutations in the OCA2 gene, is characterized by fair hair, light-colored eyes, …
UniProt
https://www.uniprot.org › uniprot
Q01726 - UniProt
Genetic variants in MC1R define the skin/hair/eye pigmentation variation locus 2 (SHEP2) [MIM:266300]. Hair, eye and skin pigmentation are among the most visible examples of …
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其他用户还问了以下问题
Where is MC1R located?
This switches pigment production from phaeomelanin to eumelanin. MC1R is maps to chromosome 16q24.3, meaning it is located on the long arm of chromosome 16, in position 24.3 near the telomere (the protective cap at the end of the chromosome that shortens with every replication) .
Melanocortin 1 receptor gene - DermNet
dermnetnz.org
What does the MC1R gene do?
The MC1R gene provides instructions for making a protein called the melanocortin 1 receptor. This receptor plays an important role in normal pigmentation. The receptor is primarily located on the surface of melanocytes, which are specialized cells that produce a pigment called melanin.
MC1R gene - MedlinePlus
medlineplus.gov
Are MC1R gene variants associated with cutaneous melanoma?
Kennedy C, ter Huurne J, Berkhout M, et al. Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color. J Invest Dermatol 2001; 117 (2): 294–300.
Melanocortin 1 receptor gene - DermNet
dermnetnz.org
What are MC1R polymorphisms?
Certain genetic variations are most common in people with red hair, fair skin, freckles, and an increased sensitivity to sun exposure. These MC1R polymorphisms reduce the ability of the melanocortin 1 receptor to stimulate eumelanin production, causing melanocytes to make mostly pheomelanin.
MC1R gene - MedlinePlus
medlineplus.gov
What does MC1R stand for?
"Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)". Life Sciences. 71 (18): 2171–2179. doi: 10.1016/S0024-3205 (02)01996-3. PMID 12204775. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008).
Melanocortin 1 receptor - Wikipedia
en.wikipedia.org
What are MC1R genetic variations?
Common variations (polymorphisms) in the MC1R gene are associated with normal differences in skin and hair color. Certain genetic variations are most common in people with red hair, fair skin, freckles, and an increased sensitivity to sun exposure.
MC1R gene - MedlinePlus
medlineplus.gov
反馈
Rat Genome Database
https://rgd.mcw.edu › rgdweb › report › gene › main.html
Mc1r (melanocortin 1 receptor) - Rat Genome Database
MC1R: three novel variants identified in a malignant melanoma association study in the Spanish population. Fernandez L, etal., Carcinogenesis. 2007 Aug;28(8):1659-64. Epub 2007 Apr 13.
PubMed
https://pubmed.ncbi.nlm.nih.gov
Melanocortin 1 Receptor (MC1R): Pharmacological and ... - PubMed
2023年7月29日 · In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti …
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
MC1R melanocortin 1 receptor [ Homo sapiens (human) ]
2016年10月9日 · Title: Molecular Basis of MC1R Activation: Mutation-Induced Alterations in Structural Dynamics. Melanoma-associated melanocortin 1 receptor variants confer redox …
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Mouse Genome Informatics
https://informatics.jax.org › marker
Mc1r MGI Mouse Gene Detail - MGI:99456
2024年12月10日 · View mouse Mc1r Chr8:124133846-124137483 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
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