In this review, we highlight key mechanisms governing the survival of post-mitotic neurons, while also detailing the physiological and pathological contexts in which neurons are capable of overcoming this high apoptotic threshold. Keywords: apoptosis, NPCs, neurons, neuronal maturation, JNK, Bcl-2, Apaf-1, caspase, XIAP, neurodegeneration.

In neurodegenerative diseases, apoptosis and necrosis are believed to be the two major death pathways for neurons [19, 20]. The fundamental differences between apoptosis and necrosis lie in the disparity of cell morphology and whether the cellular contents leak …

We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.

2015年11月5日 · Neuronal apoptosis and survival are tightly controlled processes that regulate cell fate during the development of the central nervous system and its homeostasis throughout adulthood.

2021年6月7日 · Abnormalities in PCD signalling cascades, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and cell death associated with autophagy as well as in unprogrammed necrosis can be observed in...

It has been confirmed that neuroapoptosis is included in the pathophysiology of neuronal disorders and neuropathies and is involved in most forms of cognitive problems and memory loss [80, 81].

2000年11月1日 · Many signals can initiate apoptosis in neurons, including lack of neurotrophic factor support, overactivation of glutamate receptors (leading to calcium influx), increased oxidative stress and...