We have identified a cytomegalovirus virion protein capable of modulating the rapid induction of an interferon-like response in cells that follows virus binding and penetration. Functional …

There are several tegument proteins that are of particular interest due to the role (elucidated below) that they play in the HCMV replication cycle, including pp65, pp71, pp150, and pp28. …

The lower electrophoretic mobility of pp65 in lanes RV-VM1 and RV-SB2 is caused by the insertion of a nonapeptide sequence into the primary structure of the tegument protein in these …

This study demonstrates that the HCMV tegument protein pp65 inhibits IFN-β production by binding and inactivating cGAS early during infection. In addition, this inhibitory activity …

2007年12月6日 · The tegument protein pp65 of human cytomegalovirus (HCMV) is a candidate for an efficient delivery system, as virion- and dense body-associated pp65 is presented …

The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection (PubMed:17715235). Thereafter, pp65 is probably exported and accumulates in …

1995年4月1日 · In the present study, the complete primary structure of pp65 was determined on the basis of the cDNA containing an open reading frame of 1881 bases. The sequence of …

2025年1月13日 · Understanding how HCMV employs pp65 for immune evasion could inform strategies for effective vaccine design. Research into pp65 provides insights into its functions …

Pp65 is the major tegument protein responsible for modu-lating/evading the host cell immune response during HCMV infections [19]. As reviewed in Kalejta (2008), pp65 is implicated in …

We have identified a cytomegalovirus virion protein capable of modulating the rapid induction of an interferon-like response in cells that follows virus binding and penetration. Functional …